She started acting at age 12, working extensively in Toronto, Vancouver and Los Angeles. Wilson's roles include Dr. Nikki Renholds on CBC's Republic of Doyle, Donna on the web series "My Pal Satan", and leads in St. Roz, Puck Hogs, Man v. Minivan, and 75 El Camino (the latter two were accepted at the 2009 Toronto International Film Festival). Television credits include The Two Mr. Kissels for Lifetime, and numerous starring, guest starring, and recurring roles on Breaker High, Kevin Hill, Judging Amy, Charmed, Show Me Yours, and Gideon's Crossing. Rachel also voices the character of Heather in the hit Teletoon series Total Drama. She also plays Nikki Renholds in Republic of Doyle.